購物車 
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3,4′-二羥基黃酮
- names：
3,4'-Dihydroxyflavone
- CAS號(hào)：
14919-49-4
MDL Number： MFCD00017690 - MF(分子式)： C15H10O4 MW(分子量)： 254.24
- EINECS: Reaxys Number:
- Pubchem ID:688715 Brand:BIOFOUNT
3,4′-二羥基黃酮(14919-49-4;3,4'-Dihydroxyflavone;3,4'-DHF)是一種口服活性類黃酮，3,4′-二羥基黃酮對(duì)甲型流感病毒具有抗病毒活性。
| 貨品編碼 | 規(guī)格 | 純度 | 價(jià)格 (￥) | 現(xiàn)價(jià)(￥) | 特價(jià)(￥) | 庫存描述 | 數(shù)量 | 總計(jì) (￥) |
|---|---|---|---|---|---|---|---|---|
| YZM000735-200mg | 200mg | 98.2% | ￥ 0.00 | ￥ 0.00 | Backorder | ￥ 0.00 | ||
| YZM000735-100mg | 100mg | 98.2% | ￥ 926.25 | ￥ 926.25 | 2-3天 | ￥ 0.00 |
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| 中文別名 | 3,4′-二羥基黃酮(14919-49-4);3,4'-DHF; 3-羥基-2-（4-羥基苯基）-4H-鉻-4-酮; 4'-羥基黃酮醇; |
| 英文別名 | 3,4'-Dihydroxyflavone(14919-49-4);3,4'-DHF; 3-hydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one; 4'-hydroxyflavonol; |
| CAS號(hào) | 14919-49-4 |
| Inchi | InChI = 1S / C15H10O4 / c16-10-7-5-9（6-8-10）15-14（18）13（17）11-3-1-2-4-12（11）19-15 / h1-8,16,18H |
| InchiKey | GPGOCTLAUAHUQO-UHFFFAOYSA-N |
| 分子式 Formula | C15H10O4 |
| 分子量 Molecular Weight | 254.24 |
| 溶解度Solubility | |
| 性狀 | 黃色結(jié)晶固體粉末,Power |
| 儲(chǔ)藏條件 Storage conditions | -20°C 3 years年 4°C 2 years年 / In solvent溶液中:-80°C 6 months月 -20°C 1 month月 |
3,4′-二羥基黃酮(14919-49-4;3,4'-Dihydroxyflavone;3,4'-DHF)毒性性質(zhì)：
3,4′-二羥基黃酮(14919-49-4;3,4'-Dihydroxyflavone;3,4'-DHF)實(shí)驗(yàn)注意事項(xiàng)：
1.實(shí)驗(yàn)前需戴好防護(hù)眼鏡，穿戴防護(hù)服和口罩，佩戴手套，避免與皮膚接觸。
2.實(shí)驗(yàn)過程中如遇到有毒或者刺激性物質(zhì)及有害物質(zhì)產(chǎn)生，必要時(shí)實(shí)驗(yàn)操作需要手套箱內(nèi)完成以免對(duì)實(shí)驗(yàn)人員造成傷害
3.實(shí)驗(yàn)后產(chǎn)生的廢棄物需分類存儲(chǔ)，并交于專業(yè)生物廢氣物處理公司處理，以免造成環(huán)境污染Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.
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| 產(chǎn)品說明 | 3,4′-二羥基黃酮(14919-49-4;3,4'-Dihydroxyflavone;3,4'-DHF)是一種有效的具有口服活性的黃酮類有機(jī)化合物,具有抗病毒活性 |
| Introduction | 3,4′-二羥基黃酮(14919-49-4;3,4'-Dihydroxyflavone;3,4'-DHF)is an oral active flavonoid with antiviral activity againstInfluenza A virus. |
| Application1 | |
| Application2 | |
| Application3 |
3,4′-二羥基黃酮(14919-49-4;3,4'-Dihydroxyflavone;3,4'-DHF)藥理學(xué)：
3-羥基-2-（4-羥基苯基）-4H-鉻-4--4-酮，也稱為4-羥基黃酮醇，屬于稱為黃酮醇的有機(jī)化合物。黃酮醇是含有在3-位帶有羥基的黃酮（2-苯基-1-苯并吡喃-4-酮）主鏈的化合物。3-羥基-2-（4-羥基苯基）-4H-色烯-4-酮被認(rèn)為是實(shí)際上不溶的（在水中）并且是相對(duì)中性的分子。
3-羥基-2-（4-羥基苯基）-4H-鉻-4--4-酮，也稱為4-羥基黃酮醇，屬于稱為黃酮醇的有機(jī)化合物。黃酮醇是含有在3-位帶有羥基的黃酮（2-苯基-1-苯并吡喃-4-酮）主鏈的化合物。3-羥基-2-（4-羥基苯基）-4H-色烯-4-酮被認(rèn)為是實(shí)際上不溶的（在水中）并且是相對(duì)中性的分子。
| 警示圖 | |
| 危險(xiǎn)性 | warning |
| 危險(xiǎn)性警示 | Not available |
| 安全聲明 | H303吞入可能有害+H313皮膚接觸可能有害+H2413吸入可能對(duì)身體有害 |
| 安全防護(hù) | P264處理后徹底清洗+P280戴防護(hù)手套/穿防護(hù)服/戴防護(hù)眼罩/戴防護(hù)面具+P305如果進(jìn)入眼睛+P351用水小心沖洗幾分鐘+P338取出隱形眼鏡（如果有）并且易于操作,繼續(xù)沖洗+P337如果眼睛刺激持續(xù)+P2393獲得醫(yī)療建議/護(hù)理 |
| 備注 | 實(shí)驗(yàn)過程中防止吸入、食入，做好安全防護(hù) |
3,4′-二羥基黃酮(14919-49-4;3,4'-Dihydroxyflavone;3,4'-DHF)危害標(biāo)識(shí)：
| 象形圖 |  |
| 信號(hào) | Warning |
| GHS危險(xiǎn)說明 | Aggregated GHS information provided by 5 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
| H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation] | |
| H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] | |
| H335 (80%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] | |
| Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. | |
| 防范說明代碼 | P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501 |
| (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| Hossain MK, et al. Antiviral activity of 3,4'-dihydroxyflavone on influenza a virus. J Microbiol. 2014 Jun;52(6):521-6. |
| Modulation of apoptosis in HaCaT keratinocytes via differential regulation of ERK signaling pathway by flavonoids PMID 16014620; The Journal of biological chemistry 2005 Sep; 280(36):31498-507 Name ma |
| Predictive QSAR model confirms flavonoids in Chinese medicine can activate voltage-gated calcium (CaV) channel in osteogenesis PMID 32256687; Chinese medicine 2020; 15(?):31 Name matches: isorhamnetin |
| The anti-apoptotic and anti-oxidant effect of eriodictyol on UV-induced apoptosis in keratinocytes PMID 17202655; Biological & pharmaceutical bulletin 2007 Jan; 30(1):32-7 Name matches: poly(adp-ribos |
| Modulation of apoptosis in HaCaT keratinocytes via differential regulation of ERK signaling pathway by flavonoids PMID 16014620; The Journal of biological chemistry 2005 Sep; 280(36):31498-507 Name ma |
3,4′-二羥基黃酮(14919-49-4;3,4'-Dihydroxyflavone;3,4'-DHF)參考文獻(xiàn)：
1.Antiviral activity of 3,4'-dihydroxyflavone on influenza a virus.
Hossain MK1, Choi HY, Hwang JS, Dayem AA, Kim JH, Kim YB, Poo H, Cho SG. J Microbiol. 2014 Jun;52(6):521-6. doi: 10.1007/s12275-014-4212-z. Epub 2014 May 29.
Influenza virus infection causes thousands of deaths and millions of hospitalizations worldwide every year and the emergence of resistance to anti-influenza drugs has prompted scientists to seek new natural antiviral materials. In this study, we screened 13 different flavonoids from various flavonoid groups to identify the most potent antiviral flavonoid against human influenza A/PR/8/34 (H1N1). The 3-hydroxyl group flavonoids, including 3,2?dihydroxyflavone (3,2?DHF) and 3,4?dihydroxyflavone (3,4?DHF), showed potent anti-influenza activity. They inhibited viral neuraminidase activity and viral adsorption onto cells. To confirm the anti-influenza activity of these flavonoids, we used an in vivo mouse model. In mice infected with human influenza, oral administration of 3,4?DHF significantly decreased virus titers and pathological changes in the lung and reduced body weight loss and death. Our data suggest that 3-hydroxyl group flavonoids, particularly 3,4?DHF, have potent antiviral activity against human influenza A/PR/8/34 (H1N1) in vitro and in vivo.
1.Antiviral activity of 3,4'-dihydroxyflavone on influenza a virus.
Hossain MK1, Choi HY, Hwang JS, Dayem AA, Kim JH, Kim YB, Poo H, Cho SG. J Microbiol. 2014 Jun;52(6):521-6. doi: 10.1007/s12275-014-4212-z. Epub 2014 May 29.
Influenza virus infection causes thousands of deaths and millions of hospitalizations worldwide every year and the emergence of resistance to anti-influenza drugs has prompted scientists to seek new natural antiviral materials. In this study, we screened 13 different flavonoids from various flavonoid groups to identify the most potent antiviral flavonoid against human influenza A/PR/8/34 (H1N1). The 3-hydroxyl group flavonoids, including 3,2?dihydroxyflavone (3,2?DHF) and 3,4?dihydroxyflavone (3,4?DHF), showed potent anti-influenza activity. They inhibited viral neuraminidase activity and viral adsorption onto cells. To confirm the anti-influenza activity of these flavonoids, we used an in vivo mouse model. In mice infected with human influenza, oral administration of 3,4?DHF significantly decreased virus titers and pathological changes in the lung and reduced body weight loss and death. Our data suggest that 3-hydroxyl group flavonoids, particularly 3,4?DHF, have potent antiviral activity against human influenza A/PR/8/34 (H1N1) in vitro and in vivo.
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