購物車 
-
ML303
- names：
ML303
- CAS號：
1638211-04-7
MDL Number： MFCD28168046 - MF(分子式)： C21H16F3N3O2 MW(分子量)： 399.37
- EINECS: Reaxys Number:
- Pubchem ID:136141525 Brand:BIOFOUNT
ML303(1638211-04-7)是一種吡唑并植入類化合物，ML303是流感病毒非結構蛋白1（NS1）的拮抗劑（IC90為155 nM），ML303對流感病毒H1N1亞型的EC50 額定0.7μM。
| 貨品編碼 | 規格 | 純度 | 價格 (￥) | 現價(￥) | 特價(￥) | 庫存描述 | 數量 | 總計 (￥) |
|---|---|---|---|---|---|---|---|---|
| YZM000734-5mg | 5mg | >98.0% | ￥ 0.00 | ￥ 0.00 | Backorder | ￥ 0.00 | ||
| YZM000734-1mg | 1mg | >98.0% | ￥ 2242.50 | ￥ 2242.50 | 2-3天 | ￥ 0.00 |
| 中文別名 | ML303(1638211-04-7);ML303;NCGC00248767-01;MLS004256089;AOB4452;ZINC215969162;AS-16802;ML303，> = 98％（HPLC）;SMR003080964;HY-126136;CS-0090741; |
| 英文別名 | ML303(1638211-04-7);ML303;NCGC00248767-01;MLS004256089;AOB4452;ZINC215969162;AS-16802;ML303，> = 98％（HPLC）;SMR003080964;HY-126136;CS-0090741; |
| CAS號 | 1638211-04-7 |
| Inchi | InChI = 1S / C21H16F3N3O2 / c1-12-19-16（13-3-8-17（28）18（11-13）29-2）9-10-25-20（19）27（26-12） 15-6-4-14（5-7-15）21（22,23）24 / h3-11,28H，1-2H3 |
| InchiKey | YBRHGNCGFMRGSV-UHFFFAOYSA-N |
| 分子式 Formula | C21H16F3N3O2 |
| 分子量 Molecular Weight | 399.37 |
| 溶解度Solubility | |
| 性狀 | 白色至米色粉末,Power |
| 儲藏條件 Storage conditions | 2-8°C,-20°C 3 years年 4°C 2 years年 / In solvent溶液中:-80°C 6 months月 -20°C 1 month月 |
ML303(1638211-04-7)實驗注意事項：
1.實驗前需戴好防護眼鏡，穿戴防護服和口罩，佩戴手套，避免與皮膚接觸。
2.實驗過程中如遇到有毒或者刺激性物質及有害物質產生，必要時實驗操作需要手套箱內完成以免對實驗人員造成傷害
3.實驗后產生的廢棄物需分類存儲，并交于專業生物廢氣物處理公司處理，以免造成環境污染Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.
Tags：ML303試劑,ML303雜質,ML303中間體,ML303合成,ML303密度,ML303溶解度,ML303旋光度,ML303結構式,ML303閃點,ML303購買,
| 產品說明 | ML303(1638211-04-7)是一種有效的吡唑并吡啶類有機化合物,ML303是流感病毒非結構蛋白 1 (NS1)的拮抗劑。 |
| Introduction | ML303(1638211-04-7)is a pyrazolopyridineinfluenza virus nonstructural protein 1 (NS1)antagonist (IC90= 155 nM), with anEC50of 0.7 μM for Influenza A virus H1N1. |
| Application1 | ML303(1638211-04-7)是流感病毒非結構蛋白 1 (NS1)的拮抗劑 (IC90是 155 nM)，ML303對流感病毒H1N1亞型的EC50值是0.7 μM. |
| Application2 | |
| Application3 |
ML303(1638211-04-7)藥理學：
ML303是一種吡唑并植入類化合物，ML303是流感病毒非結構蛋白1（NS1）的拮抗劑（IC90為155 nM），ML303對流感病毒H1N1亞型的EC50 額定0.7μM。
| 警示圖 | |
| 危險性 | warning |
| 危險性警示 | Not available |
| 安全聲明 | H303吞入可能有害+H313皮膚接觸可能有害+H2413吸入可能對身體有害 |
| 安全防護 | P264處理后徹底清洗+P280戴防護手套/穿防護服/戴防護眼罩/戴防護面具+P305如果進入眼睛+P351用水小心沖洗幾分鐘+P338取出隱形眼鏡（如果有）并且易于操作,繼續沖洗+P337如果眼睛刺激持續+P2393獲得醫療建議/護理 |
| 備注 | 實驗過程中防止吸入、食入，做好安全防護 |
| Patnaik S, et al. Identification, design and synthesis of novel pyrazolopyridine influenza virus nonstructural protein 1 antagonists. Bioorg Med Chem Lett. 2019 May 1;29(9):1113-1119. |
ML303(1638211-04-7)參考文獻：
1、Identification, design and synthesis of novel pyrazolopyridine influenza virus nonstructural protein 1 antagonists
Samarjit Patnaik 1, Dipanwita Basu 2, Noel Southall 3, Seameen Dehdashti 3, Kanny K Wan 3, Wei Zheng 3, Marc Ferrer 3, Mercedes Taylor 3, Daniel A Engel 4, Juan Jose Marugan
Abstract Nonstructural protein 1 (NS1) plays a crucial function in the replication, spread, and pathogenesis of influenza virus by inhibiting the host innate immune response. Here we report the discovery and optimization of novel pyrazolopyridine NS1 antagonists that can potently inhibit influenza A/PR/8/34 replication in MDCK cells, rescue MDCK cells from cytopathic effects of seasonal influenza A strains, reverse NS1-dependent inhibition of IFN-β gene expression, and suppress the slow growth phenotype in NS1-expressing yeast. These pyrazolopyridines will enable researchers to investigate NS1 function during infection and how antagonists can be utilized in the next generation of treatments for influenza infection.
1、Identification, design and synthesis of novel pyrazolopyridine influenza virus nonstructural protein 1 antagonists
Samarjit Patnaik 1, Dipanwita Basu 2, Noel Southall 3, Seameen Dehdashti 3, Kanny K Wan 3, Wei Zheng 3, Marc Ferrer 3, Mercedes Taylor 3, Daniel A Engel 4, Juan Jose Marugan
Abstract Nonstructural protein 1 (NS1) plays a crucial function in the replication, spread, and pathogenesis of influenza virus by inhibiting the host innate immune response. Here we report the discovery and optimization of novel pyrazolopyridine NS1 antagonists that can potently inhibit influenza A/PR/8/34 replication in MDCK cells, rescue MDCK cells from cytopathic effects of seasonal influenza A strains, reverse NS1-dependent inhibition of IFN-β gene expression, and suppress the slow growth phenotype in NS1-expressing yeast. These pyrazolopyridines will enable researchers to investigate NS1 function during infection and how antagonists can be utilized in the next generation of treatments for influenza infection.
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