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SP187

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names：
SP187
CAS號：
615253-61-7
MDL Number： MFCD28502268
MF(分子式)： C16H33NO5 MW(分子量)： 319.44
EINECS: Reaxys Number:
Pubchem ID:503982 Brand:BIOFOUNT

SP187(615253-61-7,SP187,MON-DNJ,UV4)是針對宿主的亞氨基糖，在體外和體內(nèi)均具有抗絲狀病毒感染的活性。SP187在體內(nèi)具有抗流感和登革熱的活性。

貨品編碼	規(guī)格	純度	價格 (￥)	現(xiàn)價(￥)	特價(￥)	庫存描述	數(shù)量	總計 (￥)
YZM000733-5mg	5mg	99.3%	￥ 6075.00	￥ 6075.00		Backorder	- +	￥ 0.00
YZM000733-1mg	1mg	99.3%	￥ 2925.00	￥ 2925.00		2-3天	- +	￥ 0.00

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中文別名	SP187(615253-61-7);MON-?DNJ; UV4;(2R，3R，4R，5S）-2-（羥甲基）-1-（9-甲氧基壬基）哌啶-3,4,5-三醇; N-9-甲氧壬基脫氧野oji霉素; SP-187；SP187; SP 187；N-9-DNJ；UV-4B；N9DNJ；UV4B；N 9 DNJ；紫外線4B;
英文別名	SP187(615253-61-7);(2R,3R,4R,5S)-2-(hydroxymethyl)-1-(9-methoxynonyl)piperidine-3,4,5-triol; N-9-Methoxynonyldeoxynojirimycin; SP-187; SP187; SP 187; N-9-DNJ; UV-4B; N9DNJ; UV4B; N 9 DNJ; UV 4B;
CAS號	615253-61-7
Inchi	InChI = 1S / C16H33NO5 / c1-22-10-8-6-4-2-3-5-7-9-17-11-14（19）16（21）15（20）13（17）12- 18 / h13-16,18-21H，2-12H2,1H3 / t13-，14 +，15-，16- / m1 / s1
InchiKey	TYTARGBBJQKLAJ-QKPAOTATSA-N
分子式 Formula	C16H33NO5
分子量 Molecular Weight	319.44
溶解度Solubility
性狀	固體粉末,Power
儲藏條件 Storage conditions	存放在陰涼干燥處，-20°C 3 years年 4°C 2 years年 / In solvent溶液中:-80°C 6 months月 -20°C 1 month月

SP187(615253-61-7,SP187,MON-DNJ,UV4)實驗注意事項：
1.實驗前需戴好防護(hù)眼鏡，穿戴防護(hù)服和口罩，佩戴手套，避免與皮膚接觸。
2.實驗過程中如遇到有毒或者刺激性物質(zhì)及有害物質(zhì)產(chǎn)生，必要時實驗操作需要手套箱內(nèi)完成以免對實驗人員造成傷害
3.實驗后產(chǎn)生的廢棄物需分類存儲，并交于專業(yè)生物廢氣物處理公司處理，以免造成環(huán)境污染Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

Tags:SP187試劑,SP187雜質(zhì),SP187中間體,SP187密度,SP187旋光度,SP187溶解度,SP187合成,SP187閃點,SP187購買,SP187MSDS,

產(chǎn)品說明	SP187(615253-61-7,SP187,MON-DNJ,UV4) 是針對宿主的亞氨基糖,在體外和體內(nèi)均具有抗絲狀病毒感染的活性。
Introduction	SP187(615253-61-7,SP187,MON-DNJ,UV4)is a hostargeted iminosugar with activity against filovirus infections in vitro and in vivo. SP187 is active against influenza and dengue in vivo.
Application1	SP187在體內(nèi)具有抗流感和登革熱的活性。
Application2
Application3

SP187(615253-61-7,SP187,MON-DNJ,UV4)藥理學(xué)：

SP187，也稱為N-9-DNJ和UV-4B，是一種針對宿主的亞氨基糖，在體外和體內(nèi)均具有抗絲狀病毒感染的活性，可用于治療登革熱和流感感染。

警示圖
危險性	warning
危險性警示	Not available
安全聲明	H303吞入可能有害+H313皮膚接觸可能有害+H2413吸入可能對身體有害
安全防護(hù)	P264處理后徹底清洗+P280戴防護(hù)手套/穿防護(hù)服/戴防護(hù)眼罩/戴防護(hù)面具+P305如果進(jìn)入眼睛+P351用水小心沖洗幾分鐘+P338取出隱形眼鏡（如果有）并且易于操作,繼續(xù)沖洗+P337如果眼睛刺激持續(xù)+P2393獲得醫(yī)療建議/護(hù)理
備注	實驗過程中防止吸入、食入，做好安全防護(hù)

SP187(615253-61-7,SP187,MON-DNJ,UV4)危害標(biāo)識：

Warfield KL, et al. Assessment of the potential for host-targeted iminosugars UV-4 and UV-5 activity against filovirus infections in vitro and in vivo. Antiviral Res. 2017 Feb;138:22-31.

Proline-hyperproducing strains of Serratia marcescens: enhancement of proline analog-mediated growth inhibition by increasing osmotic stress PMID 2860849; Applied and environmental microbiology 1985 A

A peptide-based human T cell leukemia virus type I vaccine containing T and B cell epitopes that induces high titers of neutralizing antibodies PMID 7527817; Journal of immunology (Baltimore, Md. : 19

SP187(615253-61-7,SP187,MON-DNJ,UV4)參考文獻(xiàn)：

1.A peptide-based human T cell leukemia virus type I vaccine containing T and B cell epitopes that induces high titers of neutralizing antibodies.
Baba E;Nakamura M;Ohkuma K;Kira J;Tanaka Y;Nakano S;Niho Y J Immunol. 1995 Jan 1;154(1):399-412.

We have recently identified the principal linear neutralizing B cell epitopes of human T cell leukemia virus type I (HTLV-I) on the envelope protein gp46, amino acids (aa) 187-199, by using a number of human mAbs. We therefore propose that this region would be a good candidate for a peptide-based HTLV-I vaccine. To develop a peptide-based vaccine that can induce a high titer of neutralizing Abs against HTLV-I, we first synthesized peptides of various lengths containing aa187-199. Because the addition of gp46 aa181-186 or aa200-210 to either the N-terminus or C-terminus of SP187-199 did not alter the antigenicity of the principal neutralizing determinant, we prepared two peptide-based vaccines, MAP181-203 and MAP181-210, by conjugating SP181-203 and SP181-210 with a branched polylysine oligomer. In rabbits, X4 to X8 and X8 to X64 titers of the neutralizing Abs were induced by immunization with MAP181-203 and MAP181-210, respectively. Furthermore, high titers of neutralizing Abs (X40 to X320) were elicited in five different strains of rats by immunization with MAP181-210. We also identified the major T cell epitope on gp46 aa194-210 in various strains of rats immunized with MAP181-210.

2.Proline-hyperproducing strains of Serratia marcescens: enhancement of proline analog-mediated growth inhibition by increasing osmotic stress.
Sugiura M;Kisumi M Appl Environ Microbiol. 1985 Apr;49(4):782-6.

Proline-producing strains of Serratia marcescens were more osmotolerant than wild-type strains. Growth inhibition by proline analogs was significantly enhanced by increasing the osmotic stress of the medium. Mutants resistant to azetidine-2-carboxylate were derived from a proline-producing strain, SP126, under a high osmotic condition. One of the mutants, strain SP187, produced 56 mg of L-proline per ml of medium containing sucrose and urea. This amount was ca. 3 times larger than that produced by strain SP126. The intracellular glutamate content which decreased in strain SP126 was restored in strain SP187. The glutamate dehydrogenase level of strain SP187 was 5 times higher than that of strain SP126.

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