台剧《浪漫女家教》在线观看,XXXX美国,《法国空乘11》播放

馬來酸替諾福韋

NMR下載 COA and HPLC MSDS下載
names：
Tenofovir maleate
CAS號：
1236287-04-9
MDL Number：
MF(分子式)： C13H18N5O8P MW(分子量)： 403.28
EINECS: Reaxys Number:
Pubchem ID:53302693 Brand:BIOFOUNT

馬來酸替諾福韋(1236287-04-9,Tenofovir maleate,GS 1278,PMPA)是一種抗逆轉錄病毒藥物，被稱為核苷酸類似物逆轉錄酶抑制劑（NRTIs），可阻斷逆轉錄酶，HIV-1和HBV中的關鍵病毒酶。IC50值：0.5-2.2 uM（HIV-1）；1.6-4.9 uM（HIV-2）；目標：NRTI；體外：替諾福韋水合物可降低HIV-1（IIIB），HIV-2（ROD）和HIV（EHO）的病毒細胞病變作用，EC50為1.15μg/ mL，1.12μg/ mL和1.05μg/ mL。 MT-4細胞。

貨品編碼	規格	純度	價格 (￥)	現價(￥)	特價(￥)	庫存描述	數量	總計 (￥)
YZM000693-10mg	10mg		￥ 708.00	￥ 708.00		Backorder	- +	￥ 0.00
YZM000693-5mg	5mg	>97%	￥ 453.38	￥ 453.38		2-3天	- +	￥ 0.00

大包裝詢價提供各種包裝，敬請垂詢
收藏商品商品點評加入購物車立即購買

快速詢價

收起

你想詢價的產品

*產品名稱：

CAS號：

產品編號：

需求描述：

請準確填寫您的聯系方式，以便為您提供最好的服務。

*公司名稱：

*電子郵箱：

聯系人：

*電話：

*驗證碼：

詢價

中文別名	馬來酸替諾福韋(1236287-04-9);替諾福韋(馬來酸酯);替諾福韋;替諾福韋富馬酸替索羅非酯;替諾福韋馬來酸鹽;
英文別名	Tenofovir maleate(1236287-04-9);Tenofovir (maleate);SCHEMBL16628568;HY-13910B;CS-1875; Viread maleate; GS 1278 maleate; GS1278 maleate; GS-1278 maleate; PMPA maleate; TDF maleate;
CAS號	1236287-04-9
Inchi	InChI=1S/C9H14N5O4P.C4H4O4/c1-6(18-5-19(15,16)17)2-14-4-13-7-8(10)11-3-12-9(7)14;5-3(6)1-2-4(7)8/h3-4,6H,2,5H2,1H3,(H2,10,11,12)(H2,15,16,17);1-2H,(H,5,6)(H,7,8)/b;2-1-/t6-;/m1./s1
InchiKey	OPQKUDVCYGLXAH-REVJHSINSA-N
分子式 Formula	C13H18N5O8P
分子量 Molecular Weight	403.28
溶解度Solubility
性狀	Solid
儲藏條件 Storage conditions	請根據產品建議的存儲條件進行存儲,Please store the product under the recommended condition sin the description.

馬來酸替諾福韋(1236287-04-9,Tenofovir maleate,GS 1278,PMPA)實驗注意事項：
1.實驗前需戴好防護眼鏡，穿戴防護服和口罩，佩戴手套，避免與皮膚接觸。
2.實驗過程中如遇到有毒或者刺激性物質及有害物質產生，必要時實驗操作需要手套箱內完成以免對實驗人員造成傷害
3.實驗后產生的廢棄物需分類存儲，并交于專業生物廢氣物處理公司處理，以免造成環境污染Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

Tags:GS 1278試劑,GS 1278雜質,GS 1278合成,GS 1278中間體,GS 1278密度,GS 1278溶解度,GS 1278旋光度,GS 1278購買,GS 1278閃點,

產品說明	馬來酸替諾福韋(1236287-04-9,Tenofovir maleate,GS 1278,PMPA)是一種用于治療艾滋病毒和慢性乙型肝炎的核苷酸逆轉錄酶抑制劑.
Introduction	馬來酸替諾福韋(1236287-04-9,Tenofovir maleate,GS 1278,PMPA)is a nucleotide reverse transcriptase inhibitor used to treat HIV and chronic hepatitis B.
Application1	Tenofovir (Maleate) is anucleotide reverse transcriptase inhibitorto treat HIV and chronic Hepatitis B.
Application2	Tenofovir (Maleate)是一種核苷酸逆轉錄酶抑制劑，可用于治療HIV和慢性乙型肝炎。
Application3

馬來酸替諾福韋(1236287-04-9,Tenofovir maleate,GS 1278,PMPA)藥理學：

※馬來酸替諾福韋是一種用于治療艾滋病毒和慢性乙型肝炎的核苷酸逆轉錄酶抑制劑。

※馬來酸替諾福韋(1236287-04-9,Tenofovir maleate,GS 1278,PMPA)是一種抗逆轉錄病毒藥物，被稱為核苷酸類似物逆轉錄酶抑制劑（NRTIs），可阻斷逆轉錄酶，HIV-1和HBV中的關鍵病毒酶。IC50值：0.5-2.2 uM（HIV-1）；1.6-4.9 uM（HIV-2）；目標：NRTI；體外：替諾福韋水合物可降低HIV-1（IIIB），HIV-2（ROD）和HIV（EHO）的病毒細胞病變作用，EC50為1.15μg/ mL，1.12μg/ mL和1.05μg/ mL。 MT-4細胞。

※Tenofovir hydrate reduces the viral cytopathic effect of HIV-1(IIIB), HIV-2(ROD) and HIV(EHO) with EC50 of 1.15 μg/mL, 1.12 μg/mL and 1.05 μg/mL in MT-4 cells. Tenofovir hydrate also reduces the viral cytopathic effect of SIV(mac251) , SIV(B670) ,SHIV(89.6) and SHIV(RTSHIV). Tenofovir hydrate inhibits hepatitis B virus (HBV) activity in HepG2 2.2.15, HepAD38 and HepAD79 cells. Tenofovir hydrate (4 μM) completely inhibits the growth of HIVIIIB in MT-2 cells. Tenofovir hydrate inhibits synthesis of negative strand strong-stop DNA with IC50 of 9 ?M for wild-type RT, 6 ?M for M184V RT and 50 ?M for K65R RT.
Tenofovir hydrate (30 mg/kg) completely prevents SIV infection in all macaques without toxicity. Tenofovir hydrate treatment reduces plasma viral RNA levels to undetectable, with parallel decreases in the infectivity of plasma and infectious cells in peripheral blood mononuclear cells and cerebrospinal fluid (CSF) and stabilization of CD4+ T-cell numbers. Tenofovir hydrate (30 mg/kg, s.c.) completely abrogates HIV infection via intravaginal exposure in pig-tailed macaques.

警示圖
危險性	warning
危險性警示	Not available
安全聲明	H303吞入可能有害+H313皮膚接觸可能有害+H2413吸入可能對身體有害
安全防護	P264處理后徹底清洗+P280戴防護手套/穿防護服/戴防護眼罩/戴防護面具+P305如果進入眼睛+P351用水小心沖洗幾分鐘+P338取出隱形眼鏡（如果有）并且易于操作,繼續沖洗+P337如果眼睛刺激持續+P2393獲得醫療建議/護理
備注	實驗過程中防止吸入、食入，做好安全防護

Murphy RA, et al. Establishment of HK-2 Cells as a Relevant Model to Study Tenofovir-Induced Cytotoxicity. Int J Mol Sci. 2017 Mar 1;18(3).

Musumeci G, et al. M48U1 and Tenofovir combination synergistically inhibits HIV infection in activated PBMCs and human cervicovaginal histocultures. Sci Rep. 2017 Feb 1;7:41018.

Wahl A, et al. Predicting HIV Pre-exposure Prophylaxis Efficacy for Women using a Preclinical Pharmacokinetic-Pharmacodynamic In Vivo Model. Sci Rep. 2017 Feb 1;7:41098.

Menne S, Cote PJ, Korba BE, Antiviral effect of oral administration of tenofovir disoproxil fumarate in woodchucks with chronic woodchuck hepatitis virus infection. Antimicrob Agents Chemother. 2005 J

馬來酸替諾福韋(1236287-04-9,Tenofovir maleate,GS 1278,PMPA)參考文獻：

1、An improved process for the preparation of tenofovir disoproxil and pharmaceutically acceptable salts thereof

JANEBA ZLATLO (CZ)JANSA PETR (CZ)KOLMAN VICTOR (CZ)BASZCZYNSKI ONDREJ (CZ)RAK JAKUB (CZ)

Abstract An improved process for the preparation of Tenofovir disoproxil and pharmaceutically acceptable salts thereof, comprising following steps: a) alkylation of adenine with ( R )-4-methyl-1,3-dioxolan-2-one and isolation of ( R )-1-(6-amino-9H-purin-9-yI)propan-2-ol; b) alkylation of ( R )-1-(6-amino-9H-purin-9-yl) propan-2-ol with a dialkyl p-toluenesulphonyloxymethylphosphonate or dialkyl halomethylphosphonate to give dialkylester of ( R )-9-[2-(phosphonomethoxy)propyl]adenine; c) preparation of ( R )-9-[2-(phosphonomethoxy)propyl]adenine (( R )-PMPA; Tenofovir) by dealkylation of the phosphonate moiety with a mineral acid under microwave irradiation; d) preparation of Tenofovir disoproxil; e) preparation of the fumarate salt or other pharmaceutically acceptable salt of Tenofovir disoproxil.

2、An improved process for the preparation of Tenofovir disoproxil and pharmaceutically acceptable salts thereof

JANEBA ZLATKO (CZ)JANSA PETR (CZ)KOLMAN VIKTOR (CZ)BASZCZYNSKI ONDREJ (CZ)RAK JAKUB (CZ)

Abstract An improved process for the preparation of Tenofovir disoproxil and pharmaceutically acceptable salts thereof, comprising following steps: na) alkylation of adenine with ( R )-4-methyl-1,3-dioxolan-2-one and isolation of ( R )-1-(6-amino-9 H -purin-9-yl)propan-2-ol; nb) alkylation of ( R )-1-(6-amino-9 H -purin-9-yl) propan-2-ol with a dialkyl p-toluenesulphonyloxymethylphosphonate or dialkyl halomethylphosphonate to give dialkylester of (R)-9-[2-(phosphonomethoxy)propyl]adenine; nc) preparation of (R)-9-[2-(phosphonomethoxy)propyl]adenine (( R )-PMPA; Tenofovir) by dealkylation of the phosphonate moiety with a mineral acid under microwave irradiation; nd) preparation of Tenofovir disoproxil; ne) preparation of the fumarate salt or other pharmaceutically acceptable salt of Tenofovir disoproxil.

對不起，暫無產品評價！

MSDS

SDS 1.0 中文

展開

SDS 1.0 英文

展開