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姜狀三七苷R1

NMR下載 COA and HPLC MSDS下載
names：
Zingibroside R1
CAS號：
80930-74-1
MDL Number：
MF(分子式)： C42H66O14 MW(分子量)： 794.97
EINECS: Reaxys Number:
Pubchem ID:10395524 Brand:BIOFOUNT

姜狀三七苷R1(80930-74-1,Zingibroside R1)是一種三萜類化合物，姜狀三七苷R1具有抗腫瘤，抗血管生成和抗HIV-1活性的作用。

貨品編碼	規(guī)格	純度	價格 (￥)	現(xiàn)價(￥)	特價(￥)	庫存描述	數(shù)量	總計 (￥)
YZM000680-5mg	5mg		￥ 3067.00	￥ 3067.00		Backorder	- +	￥ 0.00
YZM000680-1mg	1mg	>97%	￥ 984.75	￥ 984.75		2-3天	- +	￥ 0.00

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中文別名	姜狀三七苷R1(80930-74-1);姜狀三七皂苷R1;姜黃素R1;
英文別名	Zingibroside R1(80930-74-1);HY-N6924;28-O-deglucosyl-chikusetsusaponin V;ZINC255276197;CS-0100751;
CAS號	80930-74-1
Inchi	InChI = 1S / C42H66O14 / c1-37（2）14-16-42（36（51）52）17-15-40（6）20（21（42）18-37）8-9-24-39（ 5）12-11-25（38（3,4）23（39）10-13-41（24,40）7）54-35-32（29（47）28（46）31（55-35） 33（49）50）56-34-30（48）27（45）26（44）22（19-43）53-34 / h8,21-32,34-35,43-48H，9-19H2， 1-7H3，（H，49,50）（H，51,52）/ t21-，22 +，23-，24 +，25-，26 +，27-，28-，29-，30 +，31 -，32 +，34-，35 +，39-，40 +，41 +，42- / m0 / s1
InchiKey	WJQOMUVKRDJBGZ-COUNGWPASA-N
分子式 Formula	C42H66O14
分子量 Molecular Weight	794.97
溶解度Solubility
性狀	Solid
儲藏條件 Storage conditions	請根據(jù)產(chǎn)品建議的存儲條件進行存儲,Please store the product under the recommended condition sin the description.

姜狀三七苷R1(80930-74-1,Zingibroside R1)實驗注意事項：
1.實驗前需戴好防護眼鏡，穿戴防護服和口罩，佩戴手套，避免與皮膚接觸。
2.實驗過程中如遇到有毒或者刺激性物質(zhì)及有害物質(zhì)產(chǎn)生，必要時實驗操作需要手套箱內(nèi)完成以免對實驗人員造成傷害
3.實驗后產(chǎn)生的廢棄物需分類存儲，并交于專業(yè)生物廢氣物處理公司處理，以免造成環(huán)境污染Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

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產(chǎn)品說明	姜狀三七苷R1(80930-74-1,Zingibroside R1)是一種三萜類化合物,姜狀三七苷R1具有抗腫瘤,抗血管生成和抗HIV-1活性.
Introduction	姜狀三七苷R1(80930-74-1,Zingibroside R1)is dammaranaeype triterpenoid saponin,isolated from rhizomes,taproots,and lateral roots of Panax japonicasC.A.Meyer,
Application1	(80930-74-1)Zingibroside R1 是一種有效的三萜皂苷，分離自Panax japonicasC. A. Meyer 根部，顯示出優(yōu)異的抗腫瘤作用以及抗血管生成活性
Application2	ZingibrosideR1possesses some antiIVactivity.Zingibroside R1 has inhibitory effects on the 2eoxylucose (2G) uptake by EAT cells (IC50=91.3 μM)
Application3	shows excellent antiumor effects as well as antingiogenic activity.

姜狀三七苷R1(80930-74-1,Zingibroside R1)藥理學(xué)：

Zingibroside R1是一種三萜類化合物，具有抗腫瘤，抗血管生成和抗HIV-1活性。

警示圖
危險性	warning
危險性警示	Not available
安全聲明	H303吞入可能有害+H313皮膚接觸可能有害+H2413吸入可能對身體有害
安全防護	P264處理后徹底清洗+P280戴防護手套/穿防護服/戴防護眼罩/戴防護面具+P305如果進入眼睛+P351用水小心沖洗幾分鐘+P338取出隱形眼鏡（如果有）并且易于操作,繼續(xù)沖洗+P337如果眼睛刺激持續(xù)+P2393獲得醫(yī)療建議/護理
備注	實驗過程中防止吸入、食入，做好安全防護

Yoshizaki K, et al. Saponins composition of rhizomes, taproots, and lateral roots of Satsuma-ninjin (Panax japonicus). Chem Pharm Bull (Tokyo). 2013;61(3):344-50. Epub 2012 Dec 28

Hasegawa H, et al. Inhibitory effect of some triterpenoid saponins on glucose transport in tumor cells and its application to in vitro cytotoxic and antiviral activities. Planta Med. 1994 Jun;60 (3):2

Protective effects of oleanolic acid oligoglycosides on ethanol- or indomethacin-induced gastric mucosal lesions in rats PMID 9808070; Life sciences 1998; 63(17):PL245-50 Name matches: oleanolic acid

Structure-related inhibitory activity of oleanolic acid glycosides on gastric emptying in mice PMID 10218824; Bioorganic & medicinal chemistry 1999 Feb; 7(2):323-7 Name matches: oleanolic acid 3-o-glu

Saponins composition of rhizomes, taproots, and lateral roots of Satsuma-ninjin (Panax japonicus) PMID 23291557; Chemical & pharmaceutical bulletin 2013; 61(3):344-50 Name matches: rb1 zingibroside r1

姜狀三七苷R1(80930-74-1,Zingibroside R1)參考文獻：

1、[通過微透析和UHPLC-MS / MS分析牛膝在佐劑關(guān)節(jié)炎大鼠中的藥代動力學(xué)]
Xiang Zhan 1, Wen-Yu Wang 1, Jun Fu 1, Ran Deng 1, Feng Li 1, Xue-Jing Dai 1, Yan Wang , Hong Wu

Abstract To investigate the " drug-guide" effect of Achyranthes bidentata saponins( ABS) and geniposide( GE) in the treatment on adjuvant arthritis( AA) rats. A UHPLC-MS/MS method for the quantitative determination of GE,zingibroside R1,ginsenoside Ro and chikusetsu saponin Ⅳa in rat blood and joint dialysate was established. After single or combined administration with ABS and GE was given to AA rat model,a microdialysis sampling method for rat joint cavity and jugular vein blood vessels was established to collect microdialysis samples. Waters Acquity HSS C_(18) column was used to separate the above four components,with mobile phase as acetonitrile-0. 1% formic acid water as mobile phase for gradient elution. ESI source was adopted for mass spectra in a negative ion scanning mode. Multiple reaction monitoring( MRM) mode was applied to detect the above four components. The methodological results showed that GE,zingibroside R1,ginsenoside Ro and chikusetsu saponin Ⅳa demonstrated a good linear relationship within the concentration ranges of 2-4 000,16-4 096,14-3 584,23-5 888 μg·L-1 respectively. The precision,accuracy,stability and matrix effect of these four ingredients reached the requirements of quantitative analysis of biological samples. The pharmacokinetic results demonstrated that the combined administration of ABS and GE( 60 mg·kg~(-1)+60 mg·kg~(-1)) can increase the degree of GE in joint cavity distribution,and the AUCjoint/AUCplasmwere twice of that of single administration of GE( 60 mg·kg~(-1)),which indicated that ABS might played a vital role in GE's distribution to joint cavity. Moreover,there was no significant difference between the distribution trend of total three ABS and GE in rats. The pharmacodynamics results showed that the combined administration of ABS and GE has stronger effects on paw swelling,arthritis index and synovial pathomorphology of AA rats than single administration of GE,which suggested that ABS might improve GE's anti-inflammatory effect in AA rats. Based on the above results,ABS has a targeting effect in increasing GE's concentration in joint cavity,with a synergy in efficacy.

2、中國紅參的化學(xué)成分][Chemical constituents of Chinese red ginseng] Qi-le Zhou 1, Wei Xu 1, Xiu-Wei Yang

Abstract The chemical constituents of the Chinese red ginseng were systematically investigated by using various column chromatographic methods including D-101 macroporous adsorptive resins and open silica gel column chromatographies as well as high-performance liquid chromatography.Their chemical structures were identified by physico-chemical properties and spectral analyses.Fifty-two compounds were isolated from Chinese red ginseng decoction and identified as 20(S)-ginsenoside Rh? (1), 20(R)-ginsenoside Rh? (2), ginsenoside Rg? (3), 20(22) E-ginsenoside F? (4), ginsenoside Rk? (5), 20(22) E-ginsenoside Rh? (6), ginsenoside Rg? (7), 20(S)-ginsenoside Rf-1a(8), 20(S)-ginsenoside Rf(9), 20(R)-ginsenoside Rf(10),20(S)-notoginsenoside R? (11),20(R)-notoginsenoside R? (12), 20(S)-ginsenoside Rg? (13), 20(R)-ginsenoside Rg? (14), ginsenoside Rs? (15),ginsenoside Rs? (16),ginsenoside Rd(17),notoginsenoside R? (18),ginsenoside Re? (19), ginsenoside Re(20), 20-gluco-ginsenoside Rf(21),quinquenoside-R? (22),ginsenoside Ro methyl ester(23),ginsenoside Ro(24),ginsenoside Rb? (25),ginsenoside Rc(26),ginsenoside Rb? (27),ginsenoside Ra? (28),ginsenoside Ra? (29),ginsenoside Rb? (30),20(22)Z-ginsenoside Rh? (31),chikusetsusaponin IVa butyl ester(32), 20(22)Z-ginsenoside Rs? (33),ginsenoside Rs? (34),20(22)E-ginsenoside Rs? (35),zingibroside R1-6'-butyl ester(36), chikusetsusaponin IVa methyl ester(37),20(S)-ginsenoside Rs? (38),20(R)-ginsenoside Rs? (39),zingibroside R1-6'-methyl ester(40),ginsenoside Rz? (41),ginsenoside Rk? (42),ginsenoside Rg? (43),23-O-methylginsenoside-Rg? ? (44),12β,25-dihydroxydammar-20(22)E-ene-3-O-β-D-glucopyranosyl-(1→2)-O-β-D-glucopyranoside(45), 20(22)Z-ginsenoside F? (46),3β,12β-dihydroxydammar-20(22)E,24-diene-6-O-β-D-xylopyranosyl-(1→2)-O-β-D-glucopyranoside(47), 20(S)-ginsenoside Rg? (48),20(R)-ginsenoside Rg? (49),20(22)E-ginsenoside Rg? (50),ginsenoside-Ro-6'-butyl ester(51), and polyacetyleneginsenoside Ro(52). Compounds 8, 12, 31-33, 36, 37, 44, 45, 47 and 51 were isolated from the P. ginseng, and compounds 19, 23 and 46 were isolated from Chinese red ginseng for the first time.

3、人參皂甙Ro通過其代謝產(chǎn)物對B16F10黑色素瘤生長的抑制作用 Inhibitory Effects of Ginsenoside Ro on the Growth of B16F10 Melanoma via Its Metabolites
Si-Wen Zheng 1, Sheng-Yuan Xiao 2, Jia Wang 3, Wei Hou 1, Ying-Ping Wang

Abstract Ginsenoside Ro (Ro), a major saponin derived and isolated from Panax ginseng C.A. Meyer, exerts multiple biological activities. However, the anti-tumour efficacy of Ro remains unclear because of its poor in vitro effects. In this study, we confirmed that Ro has no anti-tumour activity in vitro. We explored the anti-tumour activity of Ro in vivo in B16F10 tumour-bearing mice. The results revealed that Ro considerably suppressed tumour growth with no significant side effects on immune organs and body weight. Zingibroside R1, chikusetsusaponin IVa, and calenduloside E, three metabolites of Ro, were detected in the plasma of Ro-treated tumour-bearing mice and showed excellent anti-tumour effects as well as anti-angiogenic activity. The results suggest that the metabolites play important roles in the anti-tumour efficacy of Ro in vivo. Additionally, the haemolysis test demonstrated that Ro has good biocompatibility. Taken together, the findings of this study demonstrate that Ro markedly suppresses the tumour growth of B16F10-transplanted tumours in vivo, and its anti-tumour effects are based on the biological activity of its metabolites. The anti-tumour efficacy of these metabolites is due, at least in part, to its anti-angiogenic activity.

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