購物車 
-
KB-5246
- names：
KB-5246
- CAS號：
119474-55-4
MDL Number： MFCD00877050 - MF(分子式)： C18H17ClFN3O4S MW(分子量)： 425.86
- EINECS: Reaxys Number:
- Pubchem ID:163306678 Brand:BIOFOUNT
KB-5246(119474-55-4,CTK0H7912)是一種四環喹諾酮，KB-5246具有抗菌活性。
| 貨品編碼 | 規格 | 純度 | 價格 (￥) | 現價(￥) | 特價(￥) | 庫存描述 | 數量 | 總計 (￥) |
|---|---|---|---|---|---|---|---|---|
| YZM000412-1mg | 1mg | >97% | ￥ 14644.50 | ￥ 14644.50 | 2-3天 | ￥ 0.00 |
| 中文別名 | KB-5246(119474-55-4);3H，8H-4-Oxa-1-thia-9b-氮雜環戊基[cd]苯-9-9-羧酸，6-氟-5-（4-甲基-1-哌嗪基）-8-氧代-，鹽酸鹽(1:1);CTK0H7912; |
| 英文別名 | KB-5246(119474-55-4);3H,8H-4-Oxa-1-thia-9b-azacyclopenta[cd]phenalene-9-carboxylicacid, 6-fluoro-5-(4-methyl-1-piperazinyl)-8-oxo-, hydrochloride (1:1);CTK0H7912; |
| CAS號 | 119474-55-4 |
| Inchi | InChI=1S/C18H18FN3O4S.ClH/c1-21-2-4-22(5-3-21)15-14(19)8-6-10(23)13(18(24)25)17-11(8)12-9(20-27-17)7-26-16(12)15;/h11-12H,2-7H2,1H3,(H,24,25);1H |
| InchiKey | URZNPRNEDQSWGC-UHFFFAOYSA-N |
| 分子式 Formula | C18H17ClFN3O4S |
| 分子量 Molecular Weight | 425.86 |
| 溶解度Solubility | |
| 性狀 | Solid |
| 儲藏條件 Storage conditions | 室溫,請根據產品建議的存儲條件進行存儲,Please store the product under the recommended condition sin the description. |
KB-5246(119474-55-4,CTK0H7912)毒理性質：
| 生物 | 測試類型 | 路線 | 報告劑量（標準化劑量） | 影響 | 資源 |
| mouse | LD50 | intravenous | 237mg/kg (237mg/kg) | Journal of Medicinal Chemistry. Vol. 35, Pg. 94, 1992. | |
| mouse | LD50 | oral | 1231mg/kg (1231mg/kg) | Journal of Medicinal Chemistry. Vol. 35, Pg. 94, 1992. |
KB-5246(119474-55-4,CTK0H7912)實驗注意事項：
1.實驗前需戴好防護眼鏡，穿戴防護服和口罩，佩戴手套，避免與皮膚接觸。
2.實驗過程中如遇到有毒或者刺激性物質及有害物質產生，必要時實驗操作需要手套箱內完成以免對實驗人員造成傷害
3.實驗后產生的廢棄物需分類存儲，并交于專業生物廢氣物處理公司處理，以免造成環境污染Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.
Tags:KB-5246試劑,KB-5246合成,KB-5246中間體,KB-5246雜質,KB-5246密度,KB-5246溶解度,KB-5246旋光度,KB-5246閃點,KB-5246熔點,KB-5246購買,
| 產品說明 | KB-5246(119474-55-4,CTK0H7912)是一種四環喹諾酮，KB-5246具有抗菌活性。 |
| Introduction | KB-5246(119474-55-4,CTK0H7912)is a tetracyclic quinolone and displays antibacterial activities. |
| Application1 | |
| Application2 | |
| Application3 |
KB-5246(119474-55-4,CTK0H7912)藥理學：
1、KB-5246是四環喹諾酮，具有抗菌活性。90％的KB-5246分離株（MIC90s）對革蘭氏陽性菌如金黃色葡萄球菌（包括耐甲氧西林的金黃色葡萄球菌，表皮葡萄球菌，肺炎鏈球菌和化膿鏈球菌）的MIC為0.39μg / mL。KB5246抑制90％的分離株的大腸桿菌，肺炎克雷伯氏菌，產酸克雷伯菌在0.10微克/ mL的濃度或更少。當添加MIC或更高濃度的KB-5246時，孵育24小時后未觀察到再生長。
2、KB-5246對肺炎鏈球菌 2132感染的50％有效劑量值為50.5 mg / kg體重。KB-5246對金黃色葡萄球菌史密斯，銅綠假單胞菌 GN11189和粘質沙雷氏菌 GN7577感染的活性與氧氟沙星相當，但大于諾氟沙星。
| 警示圖 | |
| 危險性 | warning |
| 危險性警示 | Not available |
| 安全聲明 | H303吞入可能有害+H313皮膚接觸可能有害+H2413吸入可能對身體有害 |
| 安全防護 | P264處理后徹底清洗+P280戴防護手套/穿防護服/戴防護眼罩/戴防護面具+P305如果進入眼睛+P351用水小心沖洗幾分鐘+P338取出隱形眼鏡（如果有）并且易于操作,繼續沖洗+P337如果眼睛刺激持續+P2393獲得醫療建議/護理 |
| 備注 | 實驗過程中防止吸入、食入，做好安全防護 |
| Kotera Y, et al. In vitro and in vivo antibacterial activities of KB-5246, a new tetracyclic quinolone. Antimicrob Agents Chemother. 1989 Nov;33(11):1896-900. |
KB-5246(119474-55-4,CTK0H7912)參考文獻：
1、In vitro and in vivo antibacterial activities of KB-5246, a new tetracyclic quinolone
Y Kotera 1, S Mitsuhashi
Abstract The in vitro and in vivo antibacterial activities of KB-5246, a tetracyclic quinolone, were compared with those of ciprofloxacin, ofloxacin, and norfloxacin. KB-5246 demonstrated a broad antibacterial spectrum. The in vitro activity of KB-5246 against gram-negative bacteria was higher than that of ofloxacin or norfloxacin and was comparable to that of ciprofloxacin. KB-5246 demonstrated the greatest activity against gram-positive bacteria of the four agents tested. Among Streptococcus pyogenes strains resistant to 1.56 micrograms of norfloxacin per ml, there were 26 strains susceptible to 0.2 micrograms of KB-5246 per ml. Similarly, among the Staphylococcus aureus and Staphylococcus epidermidis strains resistant to 3.13 micrograms of norfloxacin per ml, there were 23 S. aureus and 11 S. epidermidis strains susceptible to 0.39 micrograms of KB-5246 per ml. Among the Streptococcus pneumoniae and Enterococcus faecalis strains resistant to 12.5 micrograms of norfloxacin per ml, there were 5 S. pneumoniae and 10 E. faecalis strains susceptible to 0.39 micrograms of KB-5246 per ml. KB-5246 had bactericidal activity at the MIC. KB-5246 demonstrated excellent antibacterial activity against various systemic infections in mice. After oral administration, KB-5246 was as active as ofloxacin and about two times more active than norfloxacin.
1、In vitro and in vivo antibacterial activities of KB-5246, a new tetracyclic quinolone
Y Kotera 1, S Mitsuhashi
Abstract The in vitro and in vivo antibacterial activities of KB-5246, a tetracyclic quinolone, were compared with those of ciprofloxacin, ofloxacin, and norfloxacin. KB-5246 demonstrated a broad antibacterial spectrum. The in vitro activity of KB-5246 against gram-negative bacteria was higher than that of ofloxacin or norfloxacin and was comparable to that of ciprofloxacin. KB-5246 demonstrated the greatest activity against gram-positive bacteria of the four agents tested. Among Streptococcus pyogenes strains resistant to 1.56 micrograms of norfloxacin per ml, there were 26 strains susceptible to 0.2 micrograms of KB-5246 per ml. Similarly, among the Staphylococcus aureus and Staphylococcus epidermidis strains resistant to 3.13 micrograms of norfloxacin per ml, there were 23 S. aureus and 11 S. epidermidis strains susceptible to 0.39 micrograms of KB-5246 per ml. Among the Streptococcus pneumoniae and Enterococcus faecalis strains resistant to 12.5 micrograms of norfloxacin per ml, there were 5 S. pneumoniae and 10 E. faecalis strains susceptible to 0.39 micrograms of KB-5246 per ml. KB-5246 had bactericidal activity at the MIC. KB-5246 demonstrated excellent antibacterial activity against various systemic infections in mice. After oral administration, KB-5246 was as active as ofloxacin and about two times more active than norfloxacin.
對不起，暫無產品評價！
MSDS
SDS 1.0 中文
展開
SDS 1.0 英文
展開
- 相關產品
-
< >
- 推薦產品
-
< >
- 最新產品
-
< >
新聞
怎么做細胞爬片免疫組化染色實驗
細胞爬片免疫組化染色，是通過細胞爬片是讓玻片浸在細胞培養基內，細胞在玻片上生長，主要用于組織學，免疫組織化學...
2020/7/20 22:04:33
提取病毒RNA的實驗方法
提取病毒RNA方法分別有：異硫氰酸胍的提取病毒RNA方法、TRIzol LS提取法、Trizol法提取法等等...
2020/7/22 20:29:26
細胞培養耗材技術領先性
細胞培養板行業面臨的核心痛點是：常規TC處理后表面親水角隨時間衰減，影響長期培養穩定性，BIOFOUNT高分...
2026/4/28 15:12:51
細胞培養耗材關鍵性能
細胞培養板的水接觸角作為表面潤濕性的核心指標，直接影響細胞貼壁、增殖、分化及功能表達，其中40°（低接觸角/...
2026/4/28 14:52:44
chelex 100樹脂國產替代之路-BIOFOUNT范德生物
Chelex 100螯合離子交換樹脂對銅、鐵和其他重金屬?的偏好顯著高于對鈉、鉀等一價陽離子的偏好。它對二價...
2025/11/4 14:22:46
9月開學季——助研新學期 范德送好禮
2025/8/28 15:30:55
Waxfilm 實驗室封口膜：技術與國際市場的雙重突破
在實驗室耗材領域，封口膜是保障實驗準確性與穩定性的關鍵產品之一。近年來，Waxfilm?實驗室封口膜憑借其卓...
2025/5/13 13:03:40
Waxfilm實驗室封口膜的5大突破
Waxfilm實驗室封口膜作為生物功能膜領域的國產技術突破和品牌突破，是生物領域中國技術發展的縮影。
2025/5/6 17:02:07
各種微流控芯片鍵合方法的優缺點
微流控芯片鍵合：目前主要有激光焊接、熱壓鍵合、膠鍵合、超音波焊接，每種方法都有各自的優缺點。本文主要介紹聚酯...
2023/7/28 10:43:09
新一代微流控鍵合解決方案
微流控鍵合解決方案：微流控芯片制造的一個重要環節，也是最容易被忽視的--芯片鍵合。其中一個重要因素是：微流控...
2023/7/27 12:44:28
