購物車 
-
Tolytoxin
- names：
Tolytoxin
- CAS號：
127999-44-4
MDL Number： - MF(分子式)： C46H75NO13 MW(分子量)： 850.1
- EINECS: Reaxys Number:
- Pubchem ID: Brand:BIOFOUNT
| 貨品編碼 | 規格 | 純度 | 價格 (￥) | 現價(￥) | 特價(￥) | 庫存描述 | 數量 | 總計 (￥) |
|---|
| 中文別名 | N-[(E,3R,4R,5R,9S,10S,11S)-10-hydroxy-11-[(1S,3S,4S,5S,7R,8S,9R,12E,14E,16S,17R,19R)-16-hydroxy-3,5,7,17-tetramethoxy-8,14-dimethyl-11-oxospiro[10,23-dioxabicyclo[17.3.1]tricosa-12,14,20-triene-4,2'-oxirane]-9-yl]-4-methoxy-3,5,9-trimethyl-6-oxododec-1-enyl]-N-methylformamide |
| 英文別名 | Tolytoxin; 6-Hydroxy-7-O-methylscytophycin B |
| CAS號 | 127999-44-4 |
| Inchi | InChI=1S/C46H75NO13/c1-28-16-19-42(51)60-45(33(6)43(52)29(2)17-18-36(49)31(4)44(57-12)30(3)20-21-47(7)27-48)32(5)38(53-8)25-41(56-11)46(26-58-46)40(55-10)24-35-15-13-14-34(59-35)23-39(54-9)37(50)22-28/h13-14,16,19-22,27,29-35,37-41,43-45,50,52H,15,17-18,23-26H2,1-12H3/b19-16+,21-20+,28-22+/t29-,30+,31-,32-,33-,34-,35-,37-,38+,39+,40-,41-,43-,44+,45-,46-/m0/s1 |
| InchiKey | FTGOWEQDZZMPNJ-GUMZKTDUSA-N |
| 分子式 Formula | C46H75NO13 |
| 分子量 Molecular Weight | 850.1 |
| 溶解度Solubility | |
| 性狀 | Solid powder |
| 儲藏條件 Storage conditions | Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years). |
| 產品說明 | Tolytoxin(CAS:127999-44-4):僅限應用于工業或者科學研究過程中非醫療目的，不應用于人類或動物的臨床診斷以及治過程療，該產品非藥用，非食用。 |
| Introduction | Tolytoxin is a cytostatic, antifungal macrolide produced by blue-green algae of the genus Scytonema, is a potent, reversible inhibitor of cytokinesis in cultured mammalian cells |
| Application1 | |
| Application2 | |
| Application3 |
| [1]Dilsizoglu Senol A, Pepe A, Grudina C, Sassoon N, Reiko U, Bousset L, Melki R, Piel J, Gugger M, Zurzolo C. Effect of tolytoxin on tunneling nanotube formation and function. Sci Rep. 2019 Apr 5;9(1):574[1]doi: 10.1038/s41598-019-42161-6. PubMed PMID: 30952909; PubMed Central PMCID: PMC6450976. |
| [2]Crnkovic CM, May DS, Orjala J. The impact of culture conditions on growth and metabolomic profiles of freshwater cyanobacteria. J Appl Phycol. 2018 Feb;30(1):375-384. doi: 10.1007/s10811-017-1275-3. Epub 2017 Sep 14. PubMed PMID: 30294068; PubMed Central PMCID: PMC6171529. |
| [3] Swain SS, Paidesetty SK, Padhy RN. Antibacterial, antifungal and antimycobacterial compounds from cyanobacteria. Biomed Pharmacother. 2017 Jun;90:760-776. doi: 10.1016/j.biopha.2017.04.030. Epub 2017 Apr 15. Review. PubMed PMID: 28419973. |
| [4] Ueoka R, Uria AR, Reiter S, Mori T, Karbaum P, Peters EE, Helfrich EJ, Morinaka BI, Gugger M, Takeyama H, Matsunaga S, Piel J. Metabolic and evolutionary origin of actin-binding polyketides from diverse organisms. Nat Chem Biol. 2015 Sep;11(9):705-12. doi: 10.1038/nchembio.1870. Epub 2015 Aug 3. PubMed PMID: 26236936. |
| [5] Chlipala GE, Mo S, Orjala J. Chemodiversity in freshwater and terrestrial cyanobacteria - a source for drug discovery. Curr Drug Targets. 2011 Oct;12(11):1654-73. Review. PubMed PMID: 21561419; PubMed Central PMCID: PMC3244969. |
6: Kubanek J, Jensen PR, Keifer PA, Sullards MC, Collins DO, Fenical W. Seaweed resistance to microbial attack: a targeted chemical defense against marine fungi. Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):6916-21. Epub 2003 May 19. PubMed PMID: 12756301; PubMed Central PMCID: PMC165804.7: Belmont LD, Patterson GM, Drubin DG. New actin mutants allow further characterization of the nucleotide binding cleft and drug binding sites. J Cell Sci. 1999 May;112 ( Pt 9):1325-36. PubMed PMID: 10194411.8: Zhang X, Minale L, Zampella A, Smith CD. Microfilament depletion and circumvention of multiple drug resistance by sphinxolides. Cancer Res. 1997 Sep 1;57(17):3751-8. PubMed PMID: 9288783.9: Patterson GM, Bolis CM. Scytophycin production by axenic cultures of the cyanobacterium Scytonema ocellatum. Nat Toxins. 1994;2(5):280-5. PubMed PMID: 7866663.10: Smith CD, Carmeli S, Moore RE, Patterson GM. Scytophycins, novel microfilament-depolymerizing agents which circumvent P-glycoprotein-mediated multidrug resistance. Cancer Res. 1993 Mar 15;53(6):1343-7. PubMed PMID: 8095179.1
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