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Tiadenol

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names：
2,2'-(decane-1,10-diylbis(sulfanediyl))bis(ethan-1-ol)
CAS號：
6964-20-1
MDL Number：
MF(分子式)： C14H30O2S2 MW(分子量)： 294.51
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	2,2'-(decane-1,10-diylbis(sulfanediyl))bis(ethan-1-ol)
英文別名	Tiadenol; LL 1558; LL-1558; LL1558 NSC 66316; NSC-66316; NSC66316; Tiadenolum;
CAS號	6964-20-1
Inchi	InChI=1S/C14H30O2S2/c15-9-13-17-11-7-5-3-1-2-4-6-8-12-18-14-10-16/h15-16H,1-14H2
InchiKey	WRCITXQNXAIKLR-UHFFFAOYSA-N
分子式 Formula	C14H30O2S2
分子量 Molecular Weight	294.51
溶解度Solubility
性狀	Solid powder
儲藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產品說明	Tiadenol(CAS:6964-20-1):僅限應用于工業或者科學研究過程中非醫療目的，不應用于人類或動物的臨床診斷以及治過程療，該產品非藥用，非食用。
Introduction	Tiadenol is a Hypolipidemic Agent.
Application1
Application2
Application3

警示圖
危險性	Warning
危險性警示
安全聲明
安全防護
備注

[1]Maffei Facino R, Carini M, Tofanetti O. Carboxylic metabolites of tiadenol as "proximate" inducers of hepatic peroxisomal beta-oxidation activity. Pharmacol Res Commun. 1988 Apr;20(4):265-76. PubMed PMID: 3387457.

[2]Gaion RM, Murari L, Cima L, Valenti P, Da Re P. Antilipolytic activity of tiadenol-nicotinate in isolated fat cells: a comparison with its parent drugs. Drugs Exp Clin Res. 1985;11(6):407-11. PubMed PMID: 3836137.

[3] Maffei Facino R, Carini M, Tofanetti O, Casciarri I, Longoni E. Experimental studies on pharmacology, metabolism and toxicology with tiadenol-disulfoxide. Dissociation of lipid lowering effects and the induction of peroxisomal and microsomal drug-metabolizing enzymes. Arzneimittelforschung. 1987 Jun;37(6):682-91. PubMed PMID: 3663266.

[4] Berge RK, Lillehaug JR. Tiadenol-mediated induction of peroxisomal enzymes in cultured C3H/10T1/2CL8 cells and in chemically transformed C3H/10T1/2 MCA16 cells. Int J Cancer. 1985 Oct 15;36(4):489-94. PubMed PMID: 2864317.

[5] Mizuguchi H, Kudo N, Ohya T, Kawashima Y. Effects of tiadenol and di-(2-ethylhexyl)phthalate on the metabolism of phosphatidylcholine and phosphatidylethanolamine in the liver of rats: comparison with clofibric acid. Biochem Pharmacol. 1999 Apr 15;57(8):869-76. PubMed PMID: 10086319.

6: Mounie J, Goudonnet H, Bereksi-Reguig K, Escousse A, Truchot R. [Inducing effects of bis-hydroxyethylthio-1,10-decane (tiadenol) on hepatic microsomal enzymes of the rat]. J Pharmacol. 1983 Apr-Jun;14(2):171-82. French. PubMed PMID: 6408317.7: Desager JP, Costermans J, Sclavons M, Harvengt C. The metabolic fate of 14C or 35S labelled tiadenol in rabbit after i.v. and oral administration. Eur J Drug Metab Pharmacokinet. 1986 Jul-Sep;11(3):225-32. PubMed PMID: 3816878.8: Maffei Facino R, Carini M, Tofanetti O. Metabolism of the hypolipidemic agent tiadenol in man and in the rat. Arzneimittelforschung. 1986 Apr;36(4):722-8. PubMed PMID: 3718595.9: Serra T, Gavelli MS, Vitaliano E, Santini G, Catalano A, Rossi FG, Tozzi J, Caridis R, Guarini G. [Therapy of hypercholesterolemia and hypertriglyceridemia. Comparison of the lipid-lowering effect of simvastatin and tiadenol]. Clin Ter. 1990 Mar 15;132(5):307-13. Italian. PubMed PMID: 2139833.10: Accarino G, Barone L, Chieppa S, Giusti I, Nutile T, Luppino E, Visone C. [Experimental study of the hypolipidemic effect of tiadenol]. Boll Chim Farm. 1979 Dec;118(12):739-47. Italian. PubMed PMID: 552256.1

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