購物車 
-
Emicoron
- names：
13-(piperidin-1-yl)-2,5,9-tris(2-(piperidin-1-yl)ethyl)pyreno[2,1,10-def7,8,9-d'e'f']diisoquinoline-1,3,8,10(2H,9H)-tetraone
- CAS號：
1422423-23-1
MDL Number： - MF(分子式)： C52H58N6O4 MW(分子量)： 831.074
- EINECS: Reaxys Number:
- Pubchem ID: Brand:BIOFOUNT
| 貨品編碼 | 規格 | 純度 | 價格 (￥) | 現價(￥) | 特價(￥) | 庫存描述 | 數量 | 總計 (￥) |
|---|
| 中文別名 | Emicoron |
| 英文別名 | Emicoron |
| CAS號 | 1422423-23-1 |
| Inchi | InChI=1S/C52H58N6O4/c59-49-36-14-13-35-45-41(56-22-11-4-12-23-56)32-40-44-39(51(61)58(52(40)62)28-26-55-20-9-3-10-21-55)31-37-33(15-24-53-16-5-1-6-17-53)29-34-30-38(43(36)46(35)42(34)47(37)48(44)45)50(60)57(49)27-25-54-18-7-2-8-19-54/h13-14,29-32H,1-12,15-28H2 |
| InchiKey | VRQVIIJBMWLLKQ-UHFFFAOYSA-N |
| 分子式 Formula | C52H58N6O4 |
| 分子量 Molecular Weight | 831.074 |
| 溶解度Solubility | |
| 性狀 | Solid powder |
| 儲藏條件 Storage conditions | Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years). |
| 產品說明 | Emicoron(CAS:1422423-23-1):僅限應用于工業或者科學研究過程中非醫療目的，不應用于人類或動物的臨床診斷以及治過程療，該產品非藥用，非食用。 |
| Introduction | Emicoron is a multi-targeting G4 ligand. Emicoron showed Strong Antitumor Efficacy against Advanced Models of Human Colon Cancer. EMICORON showed a marked therapeutic efficacy, as it inhibited the growth of patient-derived xenografts (PDX) and orthotopic colon cancer and strongly reduced the dissemination of tumor cells to lymph nodes, intestine, stomach, and liver. EMICORON had an unprecedented antitumor activity warranting further studies of EMICORON-based combination treatments. |
| Application1 | |
| Application2 | |
| Application3 |
| [1]Porru M, Artuso S, Salvati E, Bianco A, Franceschin M, Diodoro MG, Passeri D,Orlandi A, Savorani F, D'Incalci M, Biroccio A, Leonetti C. TargetingG-Quadruplex DNA Structures by EMICORON Has a Strong Antitumor Efficacy againstAdvanced Models of Human Colon Cancer. Mol Cancer Ther. 2015 Nov;14(11):2541-51.doi: 10.1158/1535-7163.MCT-15-0253. Epub 2015 Aug 24. PubMed PMID: 26304235. |
| [2]Porru M, Zizza P, Franceschin M, Leonetti C, Biroccio A. EMICORON: Amulti-targeting G4 ligand with a promising preclinical profile. Biochim BiophysActa. 2016 Nov 9. pii: S0304-4165(16)30413-5. doi: 10.1016/j.bbagen.2016.11.010.[Epub ahead of print] PubMed PMID: 27838395. |
| [3] Franceschin M, Rizzo A, Casagrande V, Salvati E, Alvino A, Altieri A,Ciammaichella A, Iachettini S, Leonetti C, Ortaggi G, Porru M, Bianco A, BiroccioA. Aromatic core extension in the series of N-cyclic bay-substituted peryleneG-quadruplex ligands: increased telomere damage, antitumor activity, and strongselectivity for neoplastic over healthy cells. ChemMedChem. 2012Dec;7(12):2144-54. doi: 10.1002/cmdc.201200348. Epub 2012 Oct 24. PubMed PMID:23097341. |
| [4] Micheli E, Altieri A, Cianni L, Cingolani C, Iachettini S, Bianco A, LeonettiC, Cacchione S, Biroccio A, Franceschin M, Rizzo A. Perylene and coronenederivatives binding to G-rich promoter oncogene sequences efficiently reducetheir expression in cancer cells. Biochimie. 2016 Jun;12 |
| [5]223-31. doi:10.1016/j.biochi.2016.04.008. Epub 2016 Apr 13. PubMed PMID: 27086081. |
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