購物車 
-
CKD-712
- names：
(S)-1-(naphthalen-1-ylmethyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol
- CAS號：
626252-75-3
MDL Number： - MF(分子式)： C20H19NO2 MW(分子量)： 305.377
- EINECS: Reaxys Number:
- Pubchem ID: Brand:BIOFOUNT
| 貨品編碼 | 規格 | 純度 | 價格 (￥) | 現價(￥) | 特價(￥) | 庫存描述 | 數量 | 總計 (￥) |
|---|
| 中文別名 | CKD-712 |
| 英文別名 | CKD-712; CKD 712; CKD712 |
| CAS號 | 626252-75-3 |
| Inchi | InChI=1S/C20H19NO2/c22-19-11-15-8-9-21-18(17(15)12-20(19)23)10-14-6-3-5-13-4-1-2-7-16(13)14/h1-7,11-12,18,21-23H,8-10H2/t18-/m0/s1 |
| InchiKey | YGCQFKVNIBDJFW-SFHVURJKSA-N |
| 分子式 Formula | C20H19NO2 |
| 分子量 Molecular Weight | 305.377 |
| 溶解度Solubility | |
| 性狀 | Solid powder |
| 儲藏條件 Storage conditions | Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years). |
| 產品說明 | CKD-712(CAS:626252-75-3):僅限應用于工業或者科學研究過程中非醫療目的，不應用于人類或動物的臨床診斷以及治過程療，該產品非藥用，非食用。 |
| Introduction | CKD-712 is a nuclear factor NF-kappa B inhibitor potentially for the treatment of sepsis. CKD-712 induced cell growth arrest, and inhibited the invasion and motility of A549 cells as determined by cell cycle analysis, a Matrigel-coated chamber assay, and a wound-healing assay, respectively. CKD-712 suppressed MMP-9, but not MMP-2 and other NF-κB-regulated proteins involved in cancer metastasis such as VEGF. CKD-712 induced cell cycle arrest at G2M phase by suppressing cyclin A, cyclin B and CDK-1 expression. |
| Application1 | |
| Application2 | |
| Application3 |
| [1]Park SI, Kim J, Yu KS, Jang IJ, Lee S. Changes in Cardiac Function After a Single Intravenous Administration of CKD-712 in Healthy Male Volunteers. Clin Drug Investig. 2017 Feb 3. doi: 10.1007/s40261-017-0494-3. [Epub ahead of print] PubMed PMID: 28160190. |
| [2]Lee WS, Yun JW, Nagappan A, Lu JN, Kim MJ, Lee JH, Kim DH, Choi YH, Kim HJ, Chang KC, Jung JM. Synthesized tetrahydroisoquinoline alkaloid exerts anticancer effects at least in part by suppressing NF-κB-regulated proteins in A549 human lung cancer cells. Oncol Rep. 2015 Mar;33(3):1141-6. doi: 10.3892/or.2014.3658. PubMed PMID: 25482101. |
| [3] Kim YM, Tsoyi K, Jang HJ, Park EJ, Park SW, Kim HJ, Hwa JS, Chang KC. CKD712, a synthetic isoquinoline alkaloid, enhances the anti-cancer effects of paclitaxel in MDA-MB-231 cells through regulation of PTEN. Life Sci. 2014 Sep 1;112(1-2):49-58. doi: 10.1016/j.lfs.2014.07.015. PubMed PMID: 25058922. |
| [4] Hsu YH, Chang CC, Yang NJ, Lee YH, Juan SH. RhoA-mediated inhibition of vascular endothelial cell mobility: positive feedback through reduced cytosolic p21 and p27. J Cell Physiol. 2014 Oct;229(10):1455-65. doi: 10.1002/jcp.24583. PubMed PMID: 24535918. |
| [5] Choi JM, Choi YH, Kim SK, Ahn KH, Won JH, Lim JH, Jang YJ, Lee S, Kim DH, Kim DK. (S)-tetrahydroisoquinoline alkaloid inhibits LPS-induced arachidonic acid release through downregulation of cPLA2 expression. Mol Cells. 2013 Nov;36(5):400-9. doi: 10.1007/s10059-013-0078-x. PubMed PMID: 24293010; PubMed Central PMCID: PMC3887938. |
6: Sharma S, Singh M, Sharma PL. Mechanism of hyperhomocysteinemia-induced vascular endothelium dysfunction - possible dysregulation of phosphatidylinositol-3-kinase and its downstream phosphoinositide dependent kinase and protein kinase B. Eur J Pharmacol. 2013 Dec 5;721(1-3):365-72. doi: 10.1016/j.ejphar.2013.08.028. PubMed PMID: 24021535.7: Jang HJ, Tsoyi K, Kim YM, Park EJ, Park SW, Kim HJ, Lee JH, Chang KC. (S)-1-α-naphthylmethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (CKD712), promotes wound closure by producing VEGF through HO-1 induction in human dermal fibroblasts and mouse skin. Br J Pharmacol. 2013 Mar;168(6):1485-96. doi: 10.1111/bph.12031. PubMed PMID: 23088309; PubMed Central PMCID: PMC3596652.8: Lee J, Yang EJ, Shin JS, Kim DH, Lee SS, Choi IH. CKD-712, (S)-1-(α-naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, Inhibits the NF-κB Activation and Augments Akt Activation during TLR4 Signaling. Immune Netw. 2011 Dec;11(6):420-3. doi: 10.4110/in.2011.11.6.420. PubMed PMID: 22346785; PubMed Central PMCID: PMC3275714.9: Park JH, Hwang IC, Ha N, Lee S, Kim JM, Lee SS, Yu H, Lim IT, You JA, Kim DH. Effects of the anti-sepsis drug, (S)-1-(α-naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (CKD-712), on mortality, inflammation, and organ injuries in rodent sepsis models. Arch Pharm Res. 2011 Mar;34(3):485-94. doi: 10.1007/s12272-011-0318-6. PubMed PMID: 21547682.10: Im DS. A promising anti-inflammatory and anti-thrombotic drug for sepsis treatment. Arch Pharm Res. 2011 Mar;34(3):339-42. doi: 10.1007/s12272-011-0300-3. PubMed PMID: 21547664.1
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